Amoxicillin tablet typically begins to work on a sinus infection within 2 to 3 days of starting the medication. However, it can take about 7 to 10 days for the full course of the... moreAmoxicillin tablet typically begins to work on a sinus infection within 2 to 3 days of starting the medication. However, it can take about 7 to 10 days for the full course of the antibiotic to be completed and for the infection to be fully treated. It's important to take the entire prescribed course, even if you start to feel better before finishing the medication, to ensure that the infection is completely eradicated and to prevent antibiotic resistance.