Scientists first identified and recognized the importance of mRNA in 1960, and it has since been studied and explored for use in vaccines and disease therapies. But until the end... moreScientists first identified and recognized the importance of mRNA in 1960, and it has since been studied and explored for use in vaccines and disease therapies. But until the end of 2020, the two mRNA COVID-19 vaccines were approved for marketing. In the past 60 years, most people have never heard of mRNA vaccines or mRNA drugs.
Prior to the COVID-19 pandemic, Moderna was researching the use of mRNA to treat glycogen storage disease type Ia (GSD-Ia), a severe genetic metabolic disease in which patients acquire glucose- 6-phosphatase inactivation, resulting in low blood sugar in the body. In addition, it is accompanied by a series of clinical symptoms such as hepatomegaly, acidosis, hyperlipidemia, hyperuricemia, hyperlactatemia, coagulation dysfunction, developmental delay, and other life-threatening conditions.
Loveah Hernandez of Dallas, Texas, was one such unfortunate youngster who was diagnosed with GSD-Ia in the hospital at the age of 6 months when she suddenly exhibited unresponsive... less
