It's important to note that information about specific car models, including their common problems, can change over time due to new releases, recalls, or updated models. Therefore, it's recommended to check the latest and most reliable sources, such as owner reviews, automotive forums, or official service bulletins for the most current information. That being said, one common issue reported by some Lexus RX350 owners in earlier model years was related to the vehicle's transmission. Some drivers experienced problems with shifting, including rough or delayed shifting. These issues could be attributed to various factors, such as transmission fluid issues or electronic control unit (ECU) malfunctions. However, it's crucial to verify whether these concerns persist in more recent models or if there have been any official recalls or solutions implemented by Lexus.