THC, the active ingredient in marijuana works on specific parts of the brains hardware, called cannabinoid receptors. Activating a cannabinoid receptor with THC creates a bunch of cellular reactions that eventually create to the "high" that you feel when you smoke weed. Cannabinoid receptors exist throughout the brain. They are most common in parts The areas of the brain that influence pleasure, time, memory, and concentration have the highest conentration of these receptors. Smoking marijuana regularly can overwhelm these receptors and cause some negative mental effects. Studies have shown that frequent marijuana use can rewire the dopamine pleasure receptors in the brain.
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