Research shows the best time to take a probiotic is first thing in the morning before eating breakfast or before going to sleep at night. Probiotics are most effective when taken on an empty stomach. Taking probiotics at least 30 minutes before a meal will reduce the time it takes for the good bacteria to get to your gut. Probiotics are dietary supplements containing beneficial bacteria naturally occurring in your intestinal tract. Environmental factors such as stress, processed food, chemicals in our water and food, pollution, radiation, and certain medications can negatively impact the diversity and number of good bacteria in your gut. Probiotic dietary supplements aim to maintain and restore the natural diversity of your gut bacteria. When you take your probiotic matters. Consistency is key according to Breanna Woods, MS, RDN, a registered dietician with Omni-Biotic USA. For optimal health benefits of probiotics, it is best to take your supplement daily. Establishing a routine around when to take your probiotic can make it easier to remember.